Mussel-inspired dopamine-CuII coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis.

Nitric oxide (NO) is a highly potent, yet short-lived bioactive molecule with a broad spectrum of physiological functions. Continuous and controllable in situ generation of NO from vascular stent surface can effectively prevent restenosis and thrombosis after its implantation.

In this study, inspired by the adhesion and protein cross-linking in the mussel byssus, through immersing the stents into an aqueous solution with dopamine (DA) and copper ions (CuII), we developed a one-step metal-catecholamine assembled strategy to prepare a durable in situ NO-generating biomimetic coating (DA-CuII). Due to the high NO catalytic efficacy and robust chelation of CuII into the DA-CuII network, the coated stents exhibited excellent hemocompatibility.

The coating also catalytically decomposed endogenous S-nitrosothiols (RSNOs) from fresh blood, and locally generated NO for over 30 days with a flux comparable to its physiological range (0.5-4 × 10-10 mol × cm-2 × min-1).

Moreover, the optimized biomimetic coatings displayed specific cell selectivity to significantly enhance endothelial cell (EC) growth while substantially inhibit smooth muscle cell (SMC) growth and migration. This feature impressively promoted regeneration of a new endothelial cell layer after stent implantation, hence improved the anti-thrombogenic and anti-restenosis qualities of vascular stents in vivo. We envision that our long-term in situ NO-generating coatings could serve as biosurfaces for long-term prevention of stent thrombosis and restenosis.

KT 5720

B9002-.1 100 µg
EUR 232.00

KT 5720

B9002-.25 250 µg
EUR 483.00

KT 5720

B9002-.5 500 µg
EUR 818.00

KT 5823

B6673-.05 50 µg
EUR 123.00

KT 5823

B6673-.1 100 µg
EUR 190.00

KT 5823

B6673-.25 250 µg
EUR 361.00

PST- KT

PVT11358 2 ug
EUR 370.00

Plasminogen Receptor (KT) (PLGRKT) Antibody

20-abx318476
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

KT 5823 (PKG kinase inhibitor)

SIH-458-100UG 100 µg
EUR 205.00
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
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Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)

SIH-458-500UG 500 µg
EUR 569.00
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
  • Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-48T 48T
EUR 317.00

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-96T 96T
EUR 496.00

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E20317 96T
EUR 361.00

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E11201 96T
EUR 361.00

Factor XI Antibody Pair

55R-FAC11-KT 5 plates
EUR 745.00
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair

55R-FAC9-KT 5 plates
EUR 760.00
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set

55R-FIBRINO-KT set
EUR 833.00
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit

55R-MRANKL-KT 1 kit
EUR 658.00
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair

55R-VWF-KT 5 plates
EUR 775.00
Description: VWF antigen Matched Pair antibody Set for ELISA