DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Main description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present contained within the vascular amyloid deposits. Aβ40 contains of C-terminal membrane insertion space. It reveals structural transition from random coil to a α-helical establishing in a water-micelle medium.

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that occur contained within the hippocampus, neocortex, and amygdala of victims with Alzheimer′s sickness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation primarily based ion channels.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • contained within the temperature primarily based conformational analysis using Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) analysis
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a aspect of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

 

amyloid

amyloid

Reconstitution

For maximal pure put together, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Totally utterly totally different Notes

Lyophilized from 0.1% TFA in H2O

Abstract

Alzheimer’s sickness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For just a few years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology contained within the human concepts and the diploma of scientific dementia. Present advances in our understanding of the occasion of amyloid pathology have helped treatment this thriller. Substantial proof now signifies that the solubility of Aβ, and the quantity of Aβ in pretty a lot of swimming swimming swimming swimming pools, may be extra fastidiously related to sickness state.

The composition of these swimming swimming swimming swimming pools of Aβ reveals completely absolutely utterly totally different populations of amyloid deposits, and has categorical correlates with the scientific standing of the affected individual. Imaging utilized sciences, along with new amyloid imaging brokers primarily based completely utterly on the chemical establishing of histologic dyes, at the moment are making it doable to hint amyloid pathology along with sickness enchancment contained within the residing affected explicit individual. Curiously, these approaches diploma out that the Aβ deposited in AD is totally absolutely utterly totally different from that current in animal fashions.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Beta Amyloid

MO22142 100 ul
EUR 435

beta Amyloid 40 protein

30R-3013 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 42 protein

beta-Amyloid antibody

22965-100ul 100ul
EUR 390

beta Amyloid antibody

20R-AR011 250 ul
EUR 381
Description: Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-10624 1 ml
EUR 693
Description: Affinity purified Chicken polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-12571 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid Antibody

35506-100ul 100ul
EUR 390

beta Amyloid antibody

10R-7917 100 ug
EUR 322
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

10R-A124a 50 ug
EUR 1011
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

70R-AR020 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-BR019 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Beta Amyloid antibody

70R-51450 100 ul
EUR 287
Description: Purified Polyclonal Beta Amyloid antibody

Amyloid beta-Protein (1-43)

5-00662 4 x 1mg Ask for price

Amyloid beta-Protein (20-29)

5-00663 4 x 5mg Ask for price

Amyloid beta-Protein (29-40)

5-00665 4 x 1mg Ask for price

Amyloid beta-Protein (33-42)

5-00666 4 x 5mg Ask for price

Amyloid beta-Protein (42-1)

5-00667 4 x 1mg Ask for price

Amyloid beta-Protein (6-20)

5-00668 4 x 1mg Ask for price

Amyloid beta 1-42 Protein

abx060277-100ug 100 ug
EUR 759
  • Shipped within 5-10 working days.

Amyloid beta (A4) Precursor Protein

20-abx260881
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
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